Article
The utility of apolipoprotein E genotyping in the diagnosis of Alzheimer disease in a community-based case series.
Archives of neurology - 1 Dec 1999
Tsuang D, Larson E B, Bowen J, McCormick W, Teri L, Nochlin D, Leverenz J B, Peskind E R, Lim A, Raskind M A, Thompson M L, Mirra S S, Gearing M, Schellenberg G D, Kukull W
Abstract excerpt
CONTEXT: A recent collaborative study found that apolipoprotein E (APOE) genotype, in conjunction with the clinical diagnosis of Alzheimer disease (AD), was useful in improving diagnostic specificity (correctly not diagnosing AD) relative to the clinical diagnosis alone. Since these samples are particularly enriched with patients with AD and the APOE epsilon4 allele, results may not be generalizable to patients...
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