Article
A straightforward genotyping of the relevant IL28B SNPs for the prediction of hepatitis C treatment outcome.
Journal of virological methods - 1 Sept 2012
Moreira Simone, Garcia Raquel Francine Liermann, Gutberlet Andréia, Bertol Bruna Cristina, Ferreira Leslie Ecker, Pinho Mauro de Souza Leite, de França Paulo Henrique Condeixa
Abstract excerpt
A sustained virological response is not achieved by a significant proportion of chronic hepatitis C patients treated with interferon-based regimens. Due to the associated side effects and high costs, therapy response markers have been thoroughly sought. Two Single Nucleotide Polymorphisms (SNPs), rs12979860 and rs8099917, which are located upstream from the IL28B gene, have been remarkably described to have a...
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