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Article

Simultaneous genotyping of rs12979860 and rs8099917 variants near the IL28B locus associated with HCV clearance and treatment response.

The Journal of molecular diagnostics : JMD - 1 Jul 2011

Melis Roberta, Fauron Christiane, McMillin Gwendolyn, Lyon Elaine, Shirts Brian, Hubley Lindsey M, Slev Patricia R

Abstract excerpt

Recent genome-wide association studies have identified two host single-nucleotide polymorphisms (SNPs) near the IL28B gene (rs12979860 C/T and rs8099917 T/G) that are associated with sustained virological response in patients infected with the hepatitis C virus. Herein, we describe a rapid multiplexed dual-color fluorescence resonance energy transfer (FRET) probe assay that accurately genotypes for both SNPs...

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Identifiers

PMID: 21704279
DOI: 10.1016/j.jmoldx.2011.03.008
PMCID: PMC3123790

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