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In Vitro Formation and Characterization of the Skeletal Muscle α·β Tropomyosin Heterodimers

19 Jul 2012

Abstract excerpt

Tropomyosin (Tm) is a dimer made of two alpha helical chains associated into a parallel coiled-coil. In mammalian skeletal and cardiac muscle, the Tm is expressed from two separate genes to give the α- and β-Tm isoforms. These associate in vivo to form homo- (α(2)) and heterodimers (α·β) with little β(2) normally observed. The proportion of α(2) vs α·β varies across species and across muscle types from almost...

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PMID: 22812662
DOI: 10.1021/bi300340r

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