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Article

α-Tropomyosin with a D175N or E180G mutation in only one chain differs from tropomyosin with mutations in both chains.

Biochemistry - 11 Dec 2012

Janco Miro, Kalyva Athanasia, Scellini Beatrice, Piroddi Nicoletta, Tesi Chiara, Poggesi Corrado, Geeves Michael A

Abstract excerpt

α-Tropomyosin (Tm) carrying hypertrophic cardiomyopathy mutation D175N or E180G was expressed in Escherichia coli. We have assembled dimers of two polypeptide chains in vitro that carry one (αα*) or two (α*α*) copies of the mutation. We found that the presence of the mutation has little effect on dimer assembly, thereby predicting that individuals heterozygous for the Tm mutations are likely to express both αα*...

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Identifiers

PMID: 23170982
DOI: 10.1021/bi301323n
PMCID: PMC3711130

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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