Mapping the functional domains within the carboxyl terminus of alpha-tropomyosin encoded by the alternatively spliced ninth exon.

doi:10.1074/jbc.271.8.4236

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Article

Mapping the functional domains within the carboxyl terminus of alpha-tropomyosin encoded by the alternatively spliced ninth exon.

The Journal of biological chemistry - 23 Feb 1996

Hammell R L, Hitchcock-DeGregori S E

Abstract excerpt

Tropomyosins are highly conserved, coiled-coil actin binding proteins found in most eukaryotic cells. Striated and smooth muscle alpha-tropomyosins differ by the regions encoded by exons 2 and 9. Unacetylated smooth tropomyosin expressed in Escherichia coli binds actin with high affinity, whereas unacetylated striated tropomyosin requires troponin, found only in striated muscle, for strong actin binding. The...

Topics

Actomyosin
Alternative Splicing
Amino Acid Sequence
Animals
Binding Sites
Ca(2+) Mg(2+)-ATPase
Calcium
Cloning, Molecular
Escherichia coli
Exons
Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Kinetics

Molecular Sequence Data

Muscle, Skeletal

Muscle, Smooth

Plasmids

Rats

Recombinant Proteins

Source

Open in PubMed

Identifiers

PMID: 8626768
DOI: 10.1074/jbc.271.8.4236

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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