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Article

Catabolic effects of FGF-1 on chondrocytes and its possible role in osteoarthritis

25 Mar 2017

Abstract excerpt

Fibroblast growth factor 1 (FGF-1) is a classical member of the FGF family and is produced by chondrocytes cultured from osteoarthritic patients. Also, this growth factor was shown to bind to CCN family protein 2 (CCN2), which regenerates damaged articular cartilage and counteracts osteoarthritis (OA) in an animal model. However, the pathophysiological role of FGF-1 in cartilage has not been well investigated. In...

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PMID: 28343287
DOI: 10.1007/s12079-017-0384-8

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