Article
Different transcriptional strategies for ccn2/ctgf gene induction between human chondrocytic and breast cancer cell lines.
Biochimie - 1 Mar 2007
Eguchi Takanori, Kubota Satoshi, Kawata Kazumi, Mukudai Yoshiki, Ohgawara Toshihiro, Miyazono Kohei, Nakao Kyouji, Kondo Seiji, Takigawa Masaharu
Abstract excerpt
Connective tissue growth factor (CTGF/CCN2) plays a critical role in endochondral bone formation; however, CCN2 also promotes angiogenesis and bone metastasis in breast cancer. Chondrocytic HCS-2/8 cells and breast cancer MDA231 cells produce over 6 times more CCN2 than any other cell type. In this study, we demonstrate that these cell lines employ different transcriptional strategies for ccn2 gene induction....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.