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Article

CXCR4-Positive Subset of Glioma Is Enriched for Cancer Stem Cells

1 Dec 2011

Abstract excerpt

CXC chemokine receptor 4 (CXCR4) is a cell surface molecule expressed in a distinct subset of glioma cells with enhanced tumorigenicity, and it is related to many important biological activities of the tumor. We supposed that this receptor might be a cell surface "marker" for glioma stem cells. This hypothesis was tested both in vitro and in vivo. The CXCR4+ and CXCR4- subsets were sorted from three human...

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PMID: 22812188
DOI: 10.3727/096504012x13340632812631

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