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Article

CXCL12/CXCR4 promotes motility and proliferation of glioma cells

1 Jan 2010

Abstract excerpt

Glioblastoma (GBM) is the most aggressive and malignant brain tumor. Recent studies indicated that glioma samples are characterized by increased expression of CXCR4, the CXCL12/SDF-1 chemokine receptor. To better understand the role of CXCR4 in GBM biology we performed an integrated study where we simultaneously evaluate the contribution of the CXCR4/CXCL12 signaling pathway to the proliferation, survival and...

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PMID: 19923906
DOI: 10.4161/cbt.9.1.10342

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