Article
A distinct subset of glioma cell lines with stem cell-like properties reflects the transcriptional phenotype of glioblastomas and overexpresses CXCR4 as therapeutic target.
Glia - 1 Apr 2011
Schulte Alexander, Günther Hauke S, Phillips Heidi S, Kemming Dirk, Martens Tobias, Kharbanda Samir, Soriano Robert H, Modrusan Zora, Zapf Svenja, Westphal Manfred, Lamszus Katrin
Abstract excerpt
Glioblastomas contain stem-like cells that can be maintained in vitro using specific serum-free conditions. We investigated whether glioblastoma stem-like (GS) cell lines preserve the expression phenotype of human glioblastomas more closely than conventional glioma cell lines. Expression profiling revealed that a distinct subset of GS lines, which displayed a full stem-like phenotype (GSf), mirrored the...
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