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An oncolytic herpesvirus expressing a CXCR4 antagonist interferes with Glioblastoma cells stemness features and migration

2025-05-24

Abstract excerpt

<h4>ABSTRACT</h4> Glioblastoma is one of the most aggressive brain tumors. Despite the standard therapy, the survival from diagnosis remains dramatically low, especially due to relapses. Considering their capacity to escape the tumor and to migrate to the subventricular zone through a CXCR4-dependant mechanism, Glioblastoma stem-like cells (GSCs) are considered as responsible for these relapses. CXCR4 regulates b...

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Literature Corpus work
72aa4675-bed2-5bed-b9bb-8daf9f4f32d3
DOI
10.1101/2025.05.21.655102
Open publication

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