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Article

High expression of Ras-related protein 1A promotes an aggressive phenotype in colorectal cancer via PTEN/FOXO3/CCND1 pathway.

Journal of experimental & clinical cancer research : CR - 31 Jul 2018

Liu Liguo, Yan Xuebing, Wu Dapeng, Yang Yi, Li Mengcheng, Su Yang, Yang Wenchao, Shan Zezhi, Gao Yuping, Jin Zhiming

Abstract excerpt

BACKGROUND: Colorectal cancer (CRC) is a commonly diagnosed digestive malignancy worldwide. Ras-related protein 1A (RAP1A) is a member of the Ras superfamily of small GTPases and has been recently identified as a novel oncoprotein in several human malignancies. However, its specific role in CRC remains unclear. METHOD: In this study, we firstly analyzed its expression and clinical significance in a retrospective...

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Source

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Identifiers

PMID: 30064475
DOI: 10.1186/s13046-018-0827-y
PMCID: PMC6069867

Genes

FOXO3
CCND1
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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