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Article

REP1 inhibits FOXO3-mediated apoptosis to promote cancer cell survival.

Cell death & disease - 5 Jan 2017

Song Kwon-Ho, Woo Seon Rang, Chung Joon-Yong, Lee Hyo-Jung, Oh Se Jin, Hong Soon-Oh, Shim Jaegal, Kim Yong Nyun, Rho Seung Bae, Hong Seung-Mo, Cho Hanbyoul, Hibi Masahiko, Bae Dong-Jun, Kim Sang-Yeob, Kim Min Gyu, Kim Tae Woo, Bae Young-Ki

Abstract excerpt

Rab escort protein 1 (REP1) is a component of Rab geranyl-geranyl transferase 2 complex. Mutations in REP1 cause a disease called choroideremia (CHM), which is an X-linked eye disease. Although it is postulated that REP1 has functions in cell survival or death of various tissues in addition to the eye, how REP1 functions in normal and cancer cells remains to be elucidated. Here, we demonstrated that REP1 is...

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Source

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Identifiers

PMID: 28055019
DOI: 10.1038/cddis.2016.462
PMCID: PMC5386371

Genes

FOXO3
CHM

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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