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Article

Lesion-specific DNA-binding and repair activities of human O⁶-alkylguanine DNA alkyltransferase.

Nucleic acids research - 1 Oct 2012

Melikishvili Manana, Fried Michael G

Abstract excerpt

Binding experiments with alkyl-transfer-active and -inactive mutants of human O(6)-alkylguanine DNA alkyltransferase (AGT) show that it forms an O(6)-methylguanine (6mG)-specific complex on duplex DNA that is distinct from non-specific assemblies previously studied. Specific complexes with duplex DNA have a 2:1 stoichiometry that is formed without accumulation of a 1:1 intermediate. This establishes a role for...

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Identifiers

PMID: 22810209
DOI: 10.1093/nar/gks674
PMCID: PMC3467069

Genes

AGT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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