Article
Mutation analysis of isocitrate dehydrogenase in acute lymphoblastic leukemia.
Genetic testing and molecular biomarkers - 1 Aug 2012
Zhang Yiqun, Wei Hui, Tang Kejing, Lin Dong, Zhang Cuiping, Mi Yingchang, Wang Lin, Wang Cuicui, Wang Min, Wang Jianxiang
Abstract excerpt
BACKGROUND: Mutations at arginine 132 of isocitrate dehydrogenase 1/2 (IDH1/2) have recently been demonstrated to be recurrent gene alterations in acute myeloid leukemia (AML). Subsequently, this mutation was also found in a variety of other hematologic malignancies, including myelodysplastic syn...
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