Article
Molecular alterations of isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) metabolic genes and additional genetic mutations in newly diagnosed acute myeloid leukemia patients.
Journal of hematology & oncology - 7 Mar 2012
Chotirat Sadudee, Thongnoppakhun Wanna, Promsuwicha Orathai, Boonthimat Chetsada, Auewarakul Chirayu U
Abstract excerpt
BACKGROUND: Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) metabolic genes encode cytosolic and mitochondrial enzymes that catalyze the conversion of isocitrate to α-ketoglutarate. Acquired somatic mutations of IDH1 and IDH2 have recently been reported in some types of brain tumors and a small...
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