Article
The olsA gene mediates the synthesis of an ornithine lipid in Pseudomonas aeruginosa during growth under phosphate-limiting conditions, but is not involved in antimicrobial peptide susceptibility.
FEMS microbiology letters - 1 Jul 2011
Lewenza Shawn, Falsafi Reza, Bains Manjeet, Rohs Patricia, Stupak Jacek, Sprott G Dennis, Hancock Robert E W
Abstract excerpt
Pseudomonas aeruginosa responds to phosphate limitation by inducing the expression of phosphate transport systems, phosphatases, hemolysins and a DNase, many of which are important for virulence. Here we report that under phosphate-limiting conditions, P. aeruginosa produces a phosphate-free ornithine lipid (OL) as the primary membrane lipid. The olsBA (PA4350-PA4351) genes were highly induced under...
Topics
- Animals
- Caenorhabditis elegans
- Chromatography, Thin Layer
- Drug Resistance, Bacterial
- Genes, Bacterial
- Lipids
- Membrane Lipids
- Mutation
- Ornithine
- Phosphates
- Polymyxin B
- Pseudomonas Infections
- Pseudomonas aeruginosa