Article
Bacterial modification of LPS and resistance to antimicrobial peptides.
Journal of endotoxin research - 1 Jan 2001
Gunn J S
Abstract excerpt
Antimicrobial peptides (APs) are ubiquitous in nature and are thought to kill micro-organisms by affecting membrane integrity. These positively charged peptides interact with negative charges in the LPS of Gram-negative bacteria. A common mechanism of resistance to AP killing is LPS modification. These modifications include fatty acid additions, phosphoethanolamine (PEtN) addition to the core and lipid A regions,...
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