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Article

Deficiency of carboxylesterase 1/esterase-x results in obesity, hepatic steatosis, and hyperlipidemia.

Hepatology (Baltimore, Md.) - 1 Dec 2012

Quiroga Ariel D, Li Lena, Trötzmüller Martin, Nelson Randy, Proctor Spencer D, Köfeler Harald, Lehner Richard

Abstract excerpt

UNLABELLED: Increased lipogenesis, together with hyperlipidemia and increased fat deposition, contribute to obesity and associated metabolic disorders including nonalcoholic fatty liver disease. Here we show that carboxylesterase 1/esterase-x (Ces1/Es-x) plays a regulatory role in hepatic fat metabolism in the mouse. We demonstrate that Ces1/Es-x knockout mice present with increased hepatic lipogenesis and with...

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Source

Identifiers

PMID: 22806626
DOI: 10.1002/hep.25961

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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