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Article

IEX-1 deficiency induces browning of white adipose tissue and resists diet-induced obesity.

Scientific reports - 11 Apr 2016

Shahid Mohd, Javed Ammar A, Chandra David, Ramsey Haley E, Shah Dilip, Khan Mohammed F, Zhao Liping, Wu Mei X

Abstract excerpt

Chronic inflammation plays a crucial role in the pathogenesis of obesity and insulin resistance. However, the primary mediators that affect energy homeostasis remain ill defined. Here, we report an unexpected role for immediate early response gene X-1 (IEX-1), a downstream target of NF-κB, in energy metabolism. We found that IEX-1 expression was highly induced in white adipose tissue (WAT) in both epidydmal and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27063893
DOI: 10.1038/srep24135
PMCID: PMC4827096

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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