Article
A multistage genetic association study identifies breast cancer risk loci at 10q25 and 16q24.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Sept 2012
Higginbotham Kathryn S, Breyer Joan P, McReynolds Kate M, Bradley Kevin M, Schuyler Peggy A, Plummer W Dale, Freudenthal Marcia E, Trentham-Dietz Amy, Newcomb Polly A, Parl Fritz F, Sanders Melinda E, Page David L, Egan Kathleen M, Dupont William D, Smith Jeffrey R
Abstract excerpt
BACKGROUND: Heritable risk for breast cancer includes an increasing number of common, low effect risk variants. We conducted a multistage genetic association study in a series of independent epidemiologic breast cancer study populations to identify novel breast cancer risk variants. METHODS: We tested 1,162 SNPs of greatest nominal significance from stage I of the Cancer Genetic Markers of Susceptibility breast...
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