A Large-Scale, Exome-Wide Association Study of Han Chinese Women Identifies Three Novel Loci Predisposing to Breast Cancer.

doi:10.1158/0008-5472.CAN-17-1721

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A Large-Scale, Exome-Wide Association Study of Han Chinese Women Identifies Three Novel Loci Predisposing to Breast Cancer.

Cancer research - 1 Jun 2018

Zhang Bo, Chen Men-Yun, Shen Yu-Jun, Zhuo Xian-Bo, Gao Ping, Zhou Fu-Sheng, Liang Bo, Zu Jun, Zhang Qin, Suleman Sufyan, Xu Yi-Hui, Xu Min-Gui, Xu Jin-Kai, Liu Chen-Cheng, Giannareas Nikolaos, Xia Ji-Han, Zhao Yuan, Huang Zhong-Lian, Yang Zhen, Cheng Huai-Dong, Li Na, Hong Yan-Yan, Li Wei, Zhang Min-Jun, Yu Ke-Da, Li Guoliang, Sun Meng-Hong, Chen Zhen-Dong, Wei Gong-Hong, Shao Zhi-Min

Abstract excerpt

Genome-wide association studies have identified more than 90 susceptibility loci for breast cancer. However, the missing heritability is evident, and the contributions of coding variants to breast cancer susceptibility have not yet been systematically evaluated. Here, we present a large-scale whole-exome association study for breast cancer consisting of 24,162 individuals (10,055 cases and 14,107 controls). In...

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PMID: 29572226
DOI: 10.1158/0008-5472.CAN-17-1721

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CNFN
ESR1
FGFR2
TOX3
YBEY

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