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Article

Routine EGFR and KRAS Mutation analysis using COLD-PCR in non-small cell lung cancer

16 Jul 2012

Abstract excerpt

Aims: Epidermal growth factor receptor (EGFR) antagonists are particularly active in non-small cell lung cancer (NSCLC) patients with tumours bearing mutations in the EFGR gene. EGFR mutation prevalence is very low in squamous histology. Response rates using these drugs in patients with KRAS mutations are low, so available KRAS mutation information may aid treatment selection in the second-line setting. Since...

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PMID: 22805266
DOI: 10.1111/j.1742-1241.2012.02961.x

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