Article
Detection of EGFR mutations in plasma and biopsies from non-small cell lung cancer patients by allele-specific PCR assays.
BMC cancer - 28 Apr 2014
Weber Britta, Meldgaard Peter, Hager Henrik, Wu Lin, Wei Wen, Tsai Julie, Khalil Azza, Nexo Ebba, Sorensen Boe S
Abstract excerpt
BACKGROUND: Lung cancer patients with mutations in the epidermal growth factor receptor (EGFR) are primary candidates for EGFR-targeted therapy. Reliable analyses of such mutations have previously been possible only in tumour tissue. Here, we demonstrate that mutations can be detected in plasma samples with allele-specific PCR assays. METHODS: Pairs of the diagnostic biopsy and plasma obtained just prior to start...
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