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Article

Screening for EGFR and KRAS mutations in endobronchial ultrasound derived transbronchial needle aspirates in non-small cell lung cancer using COLD-PCR.

PloS one - 1 Jan 2011

Santis George, Angell Roger, Nickless Guillermina, Quinn Alison, Herbert Amanda, Cane Paul, Spicer James, Breen Ronan, McLean Emma, Tobal Khalid

Abstract excerpt

EGFR mutations correlate with improved clinical outcome whereas KRAS mutations are associated with lack of response to tyrosine kinase inhibitors in patients with non-small cell lung cancer (NSCLC). Endobronchial ultrasound (EBUS)-transbronchial needle aspiration (TBNA) is being increasingly used in the management of NSCLC. Co-amplification at lower denaturation temperature (COLD)-polymerase chain reaction (PCR)...

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Identifiers

PMID: 21949883
DOI: 10.1371/journal.pone.0025191
PMCID: PMC3176319

Genes

EGFR
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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