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Article

Association of POLK polymorphisms with platinum-based chemotherapy response and severe toxicity in non-small cell lung cancer patients.

Cell biochemistry and biophysics - 1 Nov 2014

Shao Minhua, Jin Bo, Niu Yanjie, Ye Junyi, Lu Daru, Han Baohui

Abstract excerpt

Lung cancer is the leading cause of tumor-derived death. Although target therapy is proven very efficient, traditionally platinum-based chemotherapies are still primary treatment for most patients. Platinum can suppress the tumor growth and impair normal cells together. The primary aim of the present study was to study the potential role of translesion synthesis (TLS) that might play in platinum-chemotherapy...

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Share to Antineoplastic Agents
Share to Carcinoma, Non-Small-Cell Lung

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to DNA-Directed DNA Polymerase

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Source

Identifiers

PMID: 24948471
DOI: 10.1007/s12013-014-0046-x

Genes

POLK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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