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Article

An ERCC4 regulatory variant predicts grade-3 or -4 toxicities in patients with advanced non-small cell lung cancer treated by platinum-based therapy.

International journal of cancer - 15 Mar 2018

Zhang Ruoxin, Jia Ming, Xu Yuan, Qian Danwen, Wang Mengyun, Zhu Meiling, Sun Menghong, Chang Jianhua, Wei Qingyi

Abstract excerpt

Platinum-based chemotherapy (PBC) in combination with the 3rd generation drugs is the first-line treatment for patients with advanced non-small cell lung cancer (NSCLC); however, the efficacy is severely hampered by grade 3-4 toxicities. Nucleotide excision repair (NER) pathway is the main mechanism of removing platinum-induced DNA adducts that contribute to the toxicity and outcome of PBC. We analyzed data from...

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Antineoplastic Combined Chemotherapy Protocols
Carcinoma, Non-Small-Cell Lung
Computational Biology
DNA Adducts
DNA Repair

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gastrointestinal Diseases

Hematologic Diseases

Organoplatinum Compounds

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PMID: 29134637
DOI: 10.1002/ijc.31153

Genes

ERCC4

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