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Prediction of copper transport protein 1 (CTR1) genotype on severe cisplatin induced toxicity in non-small cell lung cancer (NSCLC) patients.

Lung cancer (Amsterdam, Netherlands) - 1 Aug 2012

Xu Xiaojing, Ren Huayi, Zhou Boting, Zhao Yingchun, Yuan Ruixia, Ma Rui, Zhou Honghao, Liu Zhaoqian

Abstract excerpt

BACKGROUND: Cisplatin toxicity severely obstacles successful chemotherapy in lung cancer patients. Cisplatin uptake is considered as one of the major factors contributing to the side effects of cisplatin. Genetic variances of core genes also affect cisplatin toxicity. It has been identified that CTR1, copper transporter protein 1, plays an essential role in cisplatin uptake. The purpose of this study is to...

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Identifiers

PMID: 22516052
DOI: 10.1016/j.lungcan.2012.03.023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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