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Article

Cytochrome P450 2D6 polymorphism is a molecular genetic marker of liver cirrhosis progression.

Bulletin of experimental biology and medicine - 1 Mar 2012

Nepomnyashchikh D L, Vavilin V A, Aidagulova S V, Makarova S I, Karavaeva Yu Yu, Shchepotina E G, Postnikova O A, Nokhrina Zh V, Vinogradova E V, Lyakhovich V V

Abstract excerpt

Patients with infectious viral or toxic cirrhosis of the liver participated in complex clinical pathomorphological and molecular-genetic study aimed at the search for markers of predisposition to accelerated liver fibrosis, in which the xenobiotic biotransformation system is involved. The results demonstrate association between CYP2D6 (1846G/A) genotype and rapid cirrhosis development and indicate the necessity...

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PMID: 22803153
DOI: 10.1007/s10517-012-1595-x

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