Article
Genetic polymorphisms influencing xenobiotic metabolism and transport in patients with primary biliary cirrhosis.
Hepatology (Baltimore, Md.) - 1 Jan 2005
Kimura Yasuhiko, Selmi Carlo, Leung Patrick S C, Mao Tin K, Schauer Joseph, Watnik Mitchell, Kuriyama Shigeki, Nishioka Mikio, Ansari Aftab A, Coppel Ross L, Invernizzi Pietro, Podda Mauro, Gershwin M Eric
Abstract excerpt
Epidemiological data suggest that environmental factors may trigger autoimmunity in genetically susceptible individuals. In primary biliary cirrhosis (PBC), it has been postulated that halogenated xenobiotics can modify self-molecules, facilitating the breakdown of tolerance to mitochondrial anti...
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