Article
Role of CYP2D6 polymorphism in predicting liver fibrosis progression rate in Caucasian patients with chronic hepatitis C.
Liver international : official journal of the International Association for the Study of the Liver - 1 Apr 2006
Fishman Sigal, Lurie Yoav, Peretz Hava, Morad Tova, Grynberg Elisheva, Blendis Laurie M, Leshno Moshe, Brazowski Eli, Rosner Guy, Halpern Zamir, Oren Ran
Abstract excerpt
OBJECTIVE: Previous studies have demonstrated that CYP2D6 polymorphism is associated with liver cirrhosis. The aim of the present study was to find out whether CYP2D6*4, the poor metabolizer allele can predict fibrosis progression rate. METHODS: Seventy-five Caucasian patients with chronic hepatitis C infection were recruited. They were divided into two groups, 'fast fibrosers' and 'slow fibrosers', according to...
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