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Article

Gonadotropin stimulation contributes to an increased incidence of epimutations in ICSI-derived mice.

Human molecular genetics - 15 Oct 2012

de Waal Eric, Yamazaki Yukiko, Ingale Puraskar, Bartolomei Marisa S, Yanagimachi Ryuzo, McCarrey John R

Abstract excerpt

We previously demonstrated that intracytoplasmic sperm injection (ICSI), a type of assisted reproductive technology (ART), can induce epimutations and/or epimutant phenotypes in somatic tissues of adult mice produced by this method. In the present study, we compared the occurrence of epimutations...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22802074
DOI: 10.1093/hmg/dds287
PMCID: PMC3459467

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22802074-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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