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Article

An in vitro approach reveals molecular mechanisms underlying endocrine disruptor-induced epimutagenesis.

eLife - 3 Oct 2024

Lehle Jake D, Lin Yu-Huey, Gomez Amanda, Chavez Laura, McCarrey John R

Abstract excerpt

Endocrine disrupting chemicals (EDCs) such as bisphenol S (BPS) are xenobiotic compounds that can disrupt endocrine signaling due to steric similarities to endogenous hormones. EDCs have been shown to induce disruptions in normal epigenetic programming (epimutations) and differentially expressed genes (DEGs) that predispose disease states. Most interestingly, the prevalence of epimutations following exposure to...

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Identifiers

PMID: 39361026
DOI: 10.7554/eLife.93975
PMCID: PMC11449486

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