Article
Primary epimutations introduced during intracytoplasmic sperm injection (ICSI) are corrected by germline-specific epigenetic reprogramming.
Proceedings of the National Academy of Sciences of the United States of America - 13 Mar 2012
de Waal Eric, Yamazaki Yukiko, Ingale Puraskar, Bartolomei Marisa, Yanagimachi Ryuzo, McCarrey John R
Abstract excerpt
The use of assisted reproductive technologies (ART) has become increasingly common worldwide and is now responsible for 2-3% of children born in developed countries. Multiple reports have suggested that ART-conceived children are more likely to develop rare epigenetic disorders such as Beckwith-Wiedemann Syndrome or Angelman Syndrome, both of which involve dysregulation of imprinted genes. Anecdotal reports...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.