Two alternative mechanisms that regulate the presentation of apoptotic cell engulfment signal in Caenorhabditis elegans.

doi:10.1091/mbc.e07-02-0138

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Article

Two alternative mechanisms that regulate the presentation of apoptotic cell engulfment signal in Caenorhabditis elegans.

Molecular biology of the cell - 1 Aug 2007

Venegas Victor, Zhou Zheng

Abstract excerpt

Phosphatidylserine exposed on the surface of apoptotic mammalian cells is considered an "eat-me" signal that attracts phagocytes. The generality of using phosphatidylserine as a clearance signal for apoptotic cells in animals and the regulation of this event remain uncertain. Using ectopically expressed mouse MFG-E8, a secreted phosphatidylserine-binding protein, we detected specific exposure of...

Topics

ATP-Binding Cassette Transporters
Amino Acid Sequence
Animals
Antigens, Surface
Apoptosis
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Embryonic Development
Germ Cells
Humans
Ligands

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Membrane Proteins

Mice

Milk Proteins

Models, Biological

Molecular Sequence Data

Mutation

Phagocytosis

Source

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Identifiers

PMID: 17567952
DOI: 10.1091/mbc.e07-02-0138
PMCID: PMC1949360

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