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Article

A regression model for estimating DNA copy number applied to capture sequencing data.

Bioinformatics (Oxford, England) - 15 Sept 2012

Rigaill Guillem J, Cadot Sidney, Kluin Roelof J C, Xue Zheng, Bernards Rene, Majewski Ian J, Wessels Lodewyk F A

Abstract excerpt

MOTIVATION: Target enrichment, also referred to as DNA capture, provides an effective way to focus sequencing efforts on a genomic region of interest. Capture data are typically used to detect single-nucleotide variants. It can also be used to detect copy number alterations, which is particularly useful in the context of cancer, where such changes occur frequently. In copy number analysis, it is a common practice...

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PMID: 22796958
DOI: 10.1093/bioinformatics/bts448

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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