Article
Common variants on chromosome 9p21 are associated with normal tension glaucoma.
PloS one - 1 Jan 2012
Takamoto Mitsuko, Kaburaki Toshikatsu, Mabuchi Akihiko, Araie Makoto, Amano Shiro, Aihara Makoto, Tomidokoro Atsuo, Iwase Aiko, Mabuchi Fumihiko, Kashiwagi Kenji, Shirato Shiroaki, Yasuda Noriko, Kawashima Hidetoshi, Nakajima Fumiko, Numaga Jiro, Kawamura Yoshiya, Sasaki Tsukasa, Tokunaga Katsushi
Abstract excerpt
Although intraocular pressure (IOP) is the most definitive cause of glaucoma, a subtype of open angle glaucoma (OAG) termed normal tension glaucoma (NTG), which occurs in spite of normal IOP, accounts for a large part of glaucoma cases, especially in Japan. To find common genetic variants contributing to NTG in Japanese patients, we conducted a genome-wide association study (GWAS). We performed the first...
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