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Genetic Association at the 9p21 Glaucoma Locus Contributes to Sex Bias in Normal-Tension Glaucoma.

Investigative ophthalmology & visual science - 1 Jun 2016

Ng Soo Khai, Burdon Kathryn P, Fitzgerald Jude T, Zhou Tiger, Fogarty Rhys, Souzeau Emmanuelle, Landers John, Mills Richard A, Casson Robert J, Ridge Bronwyn, Graham Stuart L, Hewitt Alex W, Mackey David A, Healey Paul R, Wang Jie Jin, Mitchell Paul, MacGregor Stuart, Craig Jamie E

Abstract excerpt

PURPOSE: Many genome-wide association studies have identified common single nucleotide polymorphisms (SNPs) at the 9p21 glaucoma locus (CDKN2B/CDKN2B-AS1) to be significantly associated with primary open-angle glaucoma (POAG), with association being stronger in normal tension glaucoma (NTG) and advanced glaucoma. We aimed to determine whether any observed differences in genetic association at the 9p21 locus are...

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PMID: 27367510
DOI: 10.1167/iovs.16-19401

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