Article
Common variants in CDKN2B-AS1 associated with optic-nerve vulnerability of glaucoma identified by genome-wide association studies in Japanese.
PloS one - 1 Jan 2012
Nakano Masakazu, Ikeda Yoko, Tokuda Yuichi, Fuwa Masahiro, Omi Natsue, Ueno Morio, Imai Kojiro, Adachi Hiroko, Kageyama Masaaki, Mori Kazuhiko, Kinoshita Shigeru, Tashiro Kei
Abstract excerpt
BACKGROUND: To date, only a small portion of the genetic variation for primary open-angle glaucoma (POAG), the major type of glaucoma, has been elucidated. METHODS AND PRINCIPAL FINDINGS: We examined our two data sets of the genome-wide association studies (GWAS) derived from a total of 2,219 Japanese subjects. First, we performed a GWAS by analyzing 653,519 autosomal common single-nucleotide polymorphisms (SNPs)...
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