Genome-wide meta-analysis identifies 22 loci for normal tension glaucoma with significant overlap with high tension glaucoma.

doi:10.1038/s41467-024-54301-2

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Article

Genome-wide meta-analysis identifies 22 loci for normal tension glaucoma with significant overlap with high tension glaucoma.

Nature communications - 17 Nov 2024

Diaz-Torres Santiago, He Weixiong, Yu Regina, Khawaja Anthony P, Hammond Christopher J, Hysi Pirro G, Pasquale Louis R, Wu Yeda, Kubo Michiaki, Akiyama Masato, Aung Tin, Cheng Ching-Yu, Khor Chiea Chuen, Kraft Peter, Kang Jae H, Hewitt Alex W, Mackey David A, Craig Jamie E, Wiggs Janey L, Ong Jue-Sheng, MacGregor Stuart, Gharahkhani Puya

Abstract excerpt

Primary open-angle glaucoma typically presents as two subtypes. This study aimed to elucidate the shared and distinct genetic architectures of normal-tension (NTG) and high-tension glaucoma (HTG), motivated by the need to develop intraocular pressure (IOP)-independent drug targets for the disease. We conducted a comprehensive multi-ethnic meta-analysis, prioritized variants based on functional annotation, and...

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PMID: 39551815
DOI: 10.1038/s41467-024-54301-2
PMCID: PMC11570636

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