Article
Association of polymorphisms in 17 loci with primary open-angle glaucoma in Chinese and Japanese.
The British journal of ophthalmology - 20 May 2026
Chen Shu Ying, Ling Anni, Chan Poemen P, Huang Chukai, Kawashima Rumi, Usui Shinichi, Matsushita Kenji, Tam Pancy O, Young Alvin L, Yam Jason C, Nishida Kohji, Tsujikawa Motokazu, Zhang Mingzhi, Pang Chi Pui, Tham Clement C, Chen Li Jia
Abstract excerpt
PURPOSE: To evaluate the associations of single-nucleotide polymorphisms (SNPs) in 17 loci with primary open-angle glaucoma (POAG) and subtypes in Chinese and Japanese. METHODS: 17 SNPs in 17 genes, selected from a recent genome-wide association study, were genotyped in a Hong Kong Chinese cohort of 1093 POAG patients, including 557 high-tension glaucoma (HTG) and 536 normal-tension glaucoma (NTG) patients, and...
Topics
- Aged
- Female
- Humans
- Male
- Middle Aged
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Genotype
- Glaucoma, Open-Angle
- Hong Kong
- Intraocular Pressure
- Japan
- Polymorphism, Single Nucleotide