Article
Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma.
PLoS genetics - 1 Jan 2012
Wiggs Janey L, Yaspan Brian L, Hauser Michael A, Kang Jae H, Allingham R Rand, Olson Lana M, Abdrabou Wael, Fan Bao J, Wang Dan Y, Brodeur Wendy, Budenz Donald L, Caprioli Joseph, Crenshaw Andrew, Crooks Kristy, Delbono Elizabeth, Doheny Kimberly F, Friedman David S, Gaasterland Douglas, Gaasterland Terry, Laurie Cathy, Lee Richard K, Lichter Paul R, Loomis Stephanie, Liu Yutao, Medeiros Felipe A, McCarty Cathy, Mirel Daniel, Moroi Sayoko E, Musch David C, Realini Anthony, Rozsa Frank W, Schuman Joel S, Scott Kathleen, Singh Kuldev, Stein Joshua D, Trager Edward H, Vanveldhuisen Paul, Vollrath Douglas, Wollstein Gadi, Yoneyama Sachiko, Zhang Kang, Weinreb Robert N, Ernst Jason, Kellis Manolis, Masuda Tomohiro, Zack Don, Richards Julia E, Pericak-Vance Margaret, Pasquale Louis R, Haines Jonathan L
Abstract excerpt
Optic nerve degeneration caused by glaucoma is a leading cause of blindness worldwide. Patients affected by the normal-pressure form of glaucoma are more likely to harbor risk alleles for glaucoma-related optic nerve disease. We have performed a meta-analysis of two independent genome-wide association studies for primary open angle glaucoma (POAG) followed by a normal-pressure glaucoma (NPG, defined by...
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