Article
Assessment of K-ras mutation: a step toward personalized medicine for patients with colorectal cancer.
Cancer - 15 Aug 2009
Jiang Yixing, Kimchi Eric T, Staveley-O'Carroll Kevin F, Cheng Hua, Ajani Jaffer A
Abstract excerpt
Some of the most significant therapeutic advances in the treatment of cancer have occurred in the management of colorectal metastases. The introduction of new cytotoxic chemotherapeutic and biologic agents has changed the approach to these patients from both an oncologic and a surgical perspective. In addition, an understanding of the molecular mechanisms by which these agents affect tumors is developing. This...
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