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Article

Phosphatidylinositol phosphate-dependent regulation of Xenopus ENaC by MARCKS protein.

American journal of physiology. Renal physiology - 15 Sept 2012

Alli Abdel A, Bao Hui-Fang, Alli Alia A, Aldrugh Yasir, Song John Z, Ma He-Ping, Yu Ling, Al-Khalili Otor, Eaton Douglas C

Abstract excerpt

Phosphatidylinositol phosphates (PIPs) are known to regulate epithelial sodium channels (ENaC). Lipid binding assays and coimmunoprecipitation showed that the amino-terminal domain of the β- and γ-subunits of Xenopus ENaC can directly bind to phosphatidylinositol 4,5-bisphosphate (PIP(2)), phosphatidylinositol 3,4,5-trisphosphate (PIP(3)), and phosphatidic acid (PA). Similar assays demonstrated various PIPs can...

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Source

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Identifiers

PMID: 22791334
DOI: 10.1152/ajprenal.00703.2011
PMCID: PMC3468524

Genes

MARCKS
PIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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