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Article

[Role of phosphorylation of MARCKS-PSD in the secretion of MUC5AC induced by cold temperatures in human airway epithelial cells].

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences - 1 May 2012

Li Minchao, Perelman Juliy M, Zhou Xiangdong

Abstract excerpt

OBJECTIVE: To construct phosphorylation sites domain (PSD) mutant of myristoylated alaninerich C kinase substrate (MARCKS) and explore the role of transient receptor potential melastatin 8 cation channels (TRPM8) and MARCKS in cold-induced synthesis and exocytosis of mucin (MUC) 5AC. METHODS: Human placental cDNA was used as a template to amplify the full coding region of MARCKS cDNA by PCR. Ser159, Ser 163, Ser...

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Identifiers

PMID: 22659655
DOI: 10.3969/j.issn.1672-7347.2012.05.003

Genes

MARCKS
PSD
TRPM8

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