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Article

Mutations upstream of fabI in triclosan resistant Staphylococcus aureus strains are associated with elevated fabI gene expression.

BMC genomics - 30 Apr 2015

Grandgirard Denis, Furi Leonardo, Ciusa Maria Laura, Baldassarri Lucilla, Knight Daniel R, Morrissey Ian, Largiadèr Carlo R, Leib Stephen L, Oggioni Marco R

Abstract excerpt

BACKGROUND: The enoyl-acyl carrier protein (ACP) reductase enzyme (FabI) is the target for a series of antimicrobial agents including novel compounds in clinical trial and the biocide triclosan. Mutations in fabI and heterodiploidy for fabI have been shown to confer resistance in S. aureus strains in a previous study. Here we further determined the fabI upstream sequence of a selection of these strains and the...

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Identifiers

PMID: 25924916
DOI: 10.1186/s12864-015-1544-y
PMCID: PMC4415318

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Mutations upstream of fabI in triclosan resistant Staphylococcus aureus strains are associated with elevated fabI gene expression.PMID 25924916Read ↗

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