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Article

Small-colony variants: a novel mechanism for triclosan resistance in methicillin-resistant Staphylococcus aureus

28 Oct 2006

Abstract excerpt

OBJECTIVES: A little-understood mode of antimicrobial resistance in Staphylococcus aureus is the evolution of a sub-population of small-colony variants (SCVs). SCVs are a cause of persistent and recurring infections refractory to antimicrobial chemotherapy. Following the inadvertent isolation of suspected SCVs growing in the presence of triclosan we set out to evaluate the formation of these colonial mutants and...

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PMID: 17079243
DOI: 10.1093/jac/dkl450

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