Article
Fatty Acid Supplementation Reverses the Small Colony Variant Phenotype in Triclosan-Adapted Staphylococcus aureus: Genetic, Proteomic and Phenotypic Analyses.
Scientific reports - 1 Mar 2018
Bazaid Abdulrahman S, Forbes Sarah, Humphreys Gavin J, Ledder Ruth G, O'Cualain Ronan, McBain Andrew J
Abstract excerpt
Staphylococcus aureus can develop a small colony variant (SCV) phenotype in response to sub-lethal exposure to the biocide triclosan. In the current study, whole genome sequencing was performed and changes in virulence were investigated in five Staphylococcus aureus strains following repeated exposure to triclosan. Following exposure, 4/5 formed SCV and exhibited point mutations in the triclosan target gene fabI...
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