Article
The influence on DNA damage of glycaemic parameters, oral antidiabetic drugs and polymorphisms of genes involved in the DNA repair system.
Mutagenesis - 1 Sept 2013
da Silva Bruna Santos, Rovaris Diego Luiz, Bonotto Rafaela Milan, Meyer Jéssica Brasil Figueiredo, Grohe Ramona Elisa, Perassolo Magda Susana, Palazzo Roberta de Passos, Maluf Sharbel Weidner, Linden Rafael, de Andrade Fabiana Michelsen
Abstract excerpt
The hyperglycaemia seen in type 2 diabetes mellitus (DM2) is associated with increased oxidative stress and production of reactive oxygen species, both of which are factors that can provoke DNA damage. Notwithstanding, other factors, including medications and individual susceptibility, can also induce this type of DNA lesion. The objective of this study was, therefore, to investigate the influence of glycaemic...
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